Development of design methods for process development in thermal separation technology and downstream processing

A new subject area of the ITVP is the development of design methods for targeted process control, such as molecular groups, isomers, enantiomers, diastereomers, SunFules, phytoextracts, plant-made pharmaceuticals, peptides, proteins and monoclonal antibodies.

Growing economic pressure and increasing limitations of healthcare systems require far-reaching process improvements. The aim of the work is to develop novel efficient design methods, processes and apparatus concepts that allow new products to be produced effectively and existing optimization potentials in the production of synthetic and biotechnological pharmaceuticals and fine chemicals to be realized.

The field of interest is subdivided as follows:

1. design, construction and commissioning of

a) a mini-plant pilot plant and

b) a micro-plant pilot plant

2. efficient methods for process development and intensification of downstream processing

a) a mini-plant pilot plantand

b) a micro-plant pilot plant

All necessary basic operations of thermal separation technology and downstream processing, such as solid extraction, liquid-liquid extraction, distillation, adsorption, chromatography, ion exchange, selective and UF/DF membranes as well as crystallization/precipitation with filtration and drying/lyophilization are to be investigated.

Mini- and micro-plant test facilities for the individual basic operations must be designed, manufactured, measured and modeled. Existing industrial contacts/cooperations in various specialist areas enable interdisciplinary cooperation.

Contact person: Univ.- Prof. Dr.-Ing. habil. Jochen Strube