On the 3 different chemical and biotechnological component systems in
- Natural Product Extraction, e.g., Green Extraction
- Biologics Manufacturing, e.g., mAbs/CHO, Fragments/E. coli, Peptides/E. coli, pDNA/E. coli to mRNA/IVT, Virus-Like Particles VLP/HEK, Allogenic Cell Therapy/Exosomes /hMSC
- Metal Ion Purification, e.g., Urban Mining for Rare Earth Elements as well as other Strategic and Critical Raw Materials like Li, Co/Ni, Nb
For the sectors
- Bulk/Fine Chemicals
- Pharmaceuticals
- Biologics
- Natural Agrochemicals, Flavors, Cosmetics, Nutraceuticals, Remedies
We research on
- Process Development and Design, Conceptual Process Design, Theoretical Feasibility Studies, Batch and Continuous Manufacturing, Stainless Steel Equipment and Disposables
- Scale-up, Mini-Plant Piloting Experimental Feasibility Studies, Basic Engineering
- Innovative Sustainable Resilient Manufacturing Technologies
- Manufacturing Design, Operation and Support
Based on the methods
- (Total) Process Modeling and Simulation towards Digital Twins and Autonomous Operation
- Experimental Model Parameter Determination in laboratory scale (10-100 mL)
- Model Validation, Design of Experiments (DoE)/Statistics, Mini-Plant Technology
- Quality-by-Design (QbD) and Process Analytical Technology (PAT) including validation of inline methods with offline analytics
- Risk Assessment
- Scale-up and
- Prototyping
Therefore, our Offer of Service is Research and Development Cooperations as well as Project Work:
- All unit operation models available (phys-chem. based, mechanistic, rigorous)
- Efficient experimental Model Parameter Determination, few weeks – months
- PAT integration, Chemometrics and multivariate regression (e.g., PLS) development and parameterization
- QbD Application, Regulatory Support
- Exp. Model Validation with Mini-Plant Operation, Test Amount supply
- Theoretical to Experimental Feasibility Studies TRL 5-8
- Equipment Prototyping
- Digital Twin incl. choice between rigorous/hybrid, ANN, ML, PINN etc. models
- Process Control and Advanced Process Control Studies
- COGs vs. GWP evaluation
- Manufacturing Transfer Support
- Project Management Consulting, Owner’s Engineer
With the infrastructure of a Competence Center
- ATEX explosion proof Mini-Plant facility
- Bio/Gene hazard S1/S2 level facilities
- Analytics, offline and inline PAT
- Mechanical and electrical workshop
- About 30 years of experience in modeling (about 500 man years).