Forschung

On the 3 different chemical and biotechnological component systems in

1. Natural Product Extraction, e.g., Green Extraction
2. Biologics Manufacturing, e.g., mAbs/CHO, Fragments/E. coli, Peptides/E. coli, pDNA/E. coli to mRNA/IVT, Virus-Like Particles VLP/HEK, Allogenic Cell Therapy/Exosomes /hMSC
3. Metal Ion Purification, e.g., Urban Mining for Rare Earth Elements as well as other Strategic and Critical Raw Materials like Li, Co/Ni, Nb

For the sectors

1. Bulk/Fine Chemicals
2. Pharmaceuticals
3. Biologics
4. Natural Agrochemicals, Flavors, Cosmetics, Nutraceuticals, Remedies

We research on

1. Process Development and Design, Conceptual Process Design, Theoretical Feasibility Studies, Batch and Continuous Manufacturing, Stainless Steel Equipment and Disposables
2. Scale-up, Mini-Plant Piloting Experimental Feasibility Studies, Basic Engineering
3. Innovative Sustainable Resilient Manufacturing Technologies
4. Manufacturing Design, Operation and Support

Based on the methods

1. (Total) Process Modeling and Simulation towards Digital Twins and Autonomous Operation
2. Experimental Model Parameter Determination in laboratory scale (10-100 mL)
3. Model Validation, Design of Experiments (DoE)/Statistics, Mini-Plant Technology
4. Quality-by-Design (QbD) and Process Analytical Technology (PAT) including validation of inline methods with offline analytics
5. Risk Assessment
6. Scale-up and
7. Prototyping

Therefore, our Offer of Service is Research and Development Cooperations as well as Project Work:

1. All unit operation models available (phys-chem. based, mechanistic, rigorous)
2. Efficient experimental Model Parameter Determination, few weeks – months
3. PAT integration, Chemometrics and multivariate regression (e.g., PLS) development and parameterization
4. QbD Application, Regulatory Support
5. Exp. Model Validation with Mini-Plant Operation, Test Amount supply
6. Theoretical to Experimental Feasibility Studies TRL 5-8
7. Equipment Prototyping
8. Digital Twin incl. choice between rigorous/hybrid, ANN, ML, PINN etc. models
9. Process Control and Advanced Process Control Studies
10. COGs vs. GWP evaluation
11. Manufacturing Transfer Support
12. Project Management Consulting, Owner’s Engineer

With the infrastructure of a Competence Center

1. ATEX explosion proof Mini-Plant facility
2. Bio/Gene hazard S1/S2 level facilities
3. Analytics, offline and inline PAT
4. Mechanical and electrical workshop
5. About 30 years of experience in modeling (about 500 man years).