Integration of material design and process development methods for the downstream processing of recombinant proteins and MABs

This research project on material design comprises the development of novel methods for the targeted production of inorganic and organic selective auxiliary materials for thermal separation technology such as extraction agents, membranes and adsorbents. The focus here is on the characterization of material parameters and performance parameters as well as their use in basic thermal operations and the experimental determination of phase equilibria, kinetic parameters and fluid dynamic parameters as well as the modelling and simulation of basic operations in the overall processes of thermal separation technology, just like modern material concepts with the aim of process intensification.

The downstream processing of biomolecules, such as recombinant protein and antibody purifications as well as isomer and enantiomer separations from the fine chemicals and pharmaceutical industries are investigated with the aim of describing and optimizing the modelling of mass separation in conventional and monolithic media, taking into account the influence of mass transport processes and the experimental comparison of monoliths and particles.

Contact: Dipl.-Ing. Christoph Helling