Deutsch
English
FAH continuing education course 2020: Plant-based extracts - process development and production
Plant-based extracts are used on an industrial scale for the production of phytopharmaceuticals, food supplements and cosmetics. Current trends such as "natural products" and "... away from fossil fuels" are boosting the growth of these industries.
In comparison, the technology used for extract production does not reflect the latest state of knowledge. In order to maintain the current markets against the background of increasing regulatory requirements and to gain new ones, a considerable improvement in technology is required. This improvement is based on the further development of basic processes and equipment as well as the application of process design methodology based on simulation and laboratory experiments.
Date: October 18 - 21, 2020
The extraction of active ingredients for medicines, food and cosmetics from renewable raw materials is becoming increasingly important due to the expected market development and the sustainability of these processes. The technical implementation of the extraction of phytoextracts is currently characterized by empirical experience. In order to provide the existing empirical know-how with a scientific basis, the Phytoextracts course explains the design of basic operations such as solid extraction (solvent and supercritical), liquid-liquid extraction and adsorption/chromatography. The botanical, chemical and analytical principles of phytoextraction will also be covered.
Date: October 13 - 16, 2019
Date: September 15 - 18, 2019
Current developments in the field of stationary phases as well as new findings in process design through simulations, combined with laboratory experiments and/or statistical experimental design, have led to process chromatography increasingly representing an economical process alternative in both product development and production. The separation of isomers, enantiomers and diastereomers as well as the purification of phytoextracts and fermentation broths are typical applications.
The course content is taught in the form of lectures, interactive tutorials, group experiments in the laboratory and computer simulations. The target group includes scientists and technicians working with preparative chromatography on a process and production scale as well as chemists and engineers in process development.
Date: October 14-17, 2018
In the production of amino acids, peptides, proteins and monoclonal antibodies, 50-90 % of the manufacturing costs are caused by downstream processing. In process development, separation processes must be designed in a specific sequence based on the physico-chemical properties of the target molecules, impurities and secondary components. This makes it possible to increase the yield and achieve the desired purity while reducing the number of basic operations.
Downstream processing methods for complex molecules are becoming increasingly efficient and therefore more economical. Recent developments in stationary phases and production equipment as well as the latest process design methods through simulation combined with laboratory experiments have made this progress possible.
This seminar will explain the design of basic operations such as UF/DF, ion exchange and affinity membranes as well as affinity, ion exchange, immobilized metal affinity, size exclusion, hydrophobic interaction and reversed phase chromatography. These are established key technologies and are widely used as highly efficient separation processes in production. Other topics discussed include protein refolding, extractiopn and precipitation/crystallization. Virus inactivation/purification methods will also be explained.
Date: February 25-28, 2018
For synthetically produced active pharmaceutical ingredients, there is a continuing trend to switch from batchwise to continuous operation. The advantages here are higher product safety through improved process robustness, a smaller plant footprint, lower cleaning costs and idle times due to modular and flexible plants.
For the production of biopharmaceuticals, such as monoclonal antibodies, continuous perfusion has already become more established as a manufacturing variant than is publicly known. It is therefore logical to apply continuous process concepts to downstream as well. In the production of biomolecules, these concepts have so far only become established for high-volume bulk or fine chemicals. The imminent cost problems in the production of biotherapeutics due to competition with low cost generic producers or personalized medicine approaches have led to first studies on continuous manufacturing for amino acids, peptides and monoclonal antibodies as well as their fragments.
This course describes design and scheduling of basic operations in continuous manufacturing processes compared to classical batch plants and aims to provide feasible decision criteria.
Date: February 25-28, 2018