Prof. Dr. Martin Tegtmeier

Schaper & Brümmer GmbH & Co. KG, Salzgitter

Natural Product Extraction, Pharmaceutical Technology

  • BioVT III (SS) and
  • BioVT IV (WS)"

  • Phytotechnology, including extraction and subsequent processes, plant ingredients

  • Phytopharmaceuticals, including conception, metabolism, formulation

  • Regulatory issues for medicinal products, including work as a qualified person (GMP/GDP)

  • Stability of (herbal) medicinal products

  • Member of the phytoextracts working group of Dechema, DGPT, DPhG

Publications

  • Processes (2023)
    Is Regulatory Approval without Autonomous Operation for Natural Extract Manufacturing under Economic Competitiveness and Climate-Neutrality Demands Still Permissible?
    A. Uhl, L. Knierim, M. Tegtmeier, A. Schmidt, J. Strube
  • Processes (2023)
    Establishment of a Research Focus on Resilient Sustainable Climate Neutral Agricultural Production - Resilient Farming Initiative
    A. Uhl, A. Schmidt, M. Tegtmeier, A. Wenzel, F. Beneke, J. Strube
  • Pharmaceutics (2023)
    Green manufacturing for herbal remedies with advanced pharmaceutical technology
    M. Tegtmeier, L. Knierim, A. Schmidt, J. Strube
  • Editio Cantor Verlag Aulendorf, 4th edition (2022)
    Stabilitätsprüfung in der Pharmazie
    W. Grimm, M. Tegtmeier (2022)
  • Processes (2021)
    Development of a General PAT Strategy for Online Monitoring of Complex Mixtures - On the Example of Natural Product Extracts from Bearberry Leaf (Arcotstaphylos uva-ursi)
    C. Jensch, L. Knierim, M. Tegtmeier, J. Strube
  • Deutscher Apotheker Verlag Stuttgart¸13th edition (2021)
    Drug forms obtained by drug extraction
    In: A. Fahr (ed.) Voigt - Pharmazeutische Technologie, pp. 559-584
    M. Tegtmeier
  • EP Patent 2431541 B1
    Process for the application of an active ingredient in shower water
    M. Tegtmeier
  • Processes (2020)
    Digital Twin for Extraction Process Design and Operation
    L. Uhlenbrock, C. Jensch, M. Tegtmeier, J. Strube
  • Zeitschrift für Arznei- und Gewürzpflanzen 24 (2020), pp. 122-126
    Are pyrrolizidine alkaloids an incalculable risk or a controllable everyday problem?
    M. Tegtmeier
  • Mining Report Glückauf 155 (2019) pp. 13-17
    Underground Farming
    O. Langefeld, M. Tegtmeier
  • Pharmazeutische Industrie 81 (2019), pp. 1340-1344
    Confirmation of GACP Compliance for Cultivation and Collection of Medicinal Plants
    F. Waimer, P. Torres Londono, S. Drewes, H. Gerke, S. Mau, B. Wagner, B. Steinhoff, N. Hadzifezovic, B. Klier, M. Preisitsch, M. Tegtmeier, C. Valder
  • Processes (2018)
    Natural Products Extraction of the Future - Sustainable Manufacturing Solutions for Societal Needs
    L. Uhlenbrock, M. Sixt, M. Tegtmeier, H. Schulz, H. Hagels, R. Ditz, J. Strube
  • Pharmazeutische Industrie 79 (2017), pp. 66-70
    Qualification of suppliers of cultivated and wild collected medicinal plants
    M. Raiser, W. Hofmann, G. Stekly, M. Tegtmeier, P. Torres Londono, B. Steinhoff
  • Pharmazeutische Industrie 79 (2017), pp. 71-74
    Re-use of extraction solvents in the manufacture of herbal extracts
    S. Bauer, A. Herde, P. Schlegel, M. Daniel, M. Tegtmeier, N. Brand, B. Steinhoff
  • Wissenschaftliche Verlagsgesellschaft Stuttgart, 6th edition (2016)
    Extrakte und Extraktherstellung
    In: W. Blaschek (ed.) Wichtl - Teedrogen und Phytopharmaka, pp. 27-32
    M. Tegtmeier
  • Pharmazeutische Industrie 78 (2016), pp. 269-278
    Development of phytopharmaceuticals
    M. Tegtmeier
  • Zeitschrift für Arznei- und Gewürzpflanzen 21 (2016), p. 62-67
    Workshop "Pyrrolizidine alkaloids - current status of starting materials for herbal medicinal products and their preparations as well as measures to reduce exposure in agriculture" in Bonn
    B. Grohs, M. Tegtmeier
  • Pharmazeutische Industrie 78 (2016), pp. 1319-1322
    Pyrrolizidine alkaloids in herbal medicinal products: A challenge for the cultivation and processing industry
    B. Grohs, B. Steinhoff, M. Tegtmeier
  • Wiley-VCH Weinheim, 1st edition (2015)
    Process engineering and product design for green extraction
    In: F. Chemat, J. Strube (eds.) Green Extraction of Natural Products, pp. 37-70
    pp. Both, R. Ditz, M. Tegtmeier, U. Jenelten, J. Strube,
  • Pharmazeutische Industrie 76 (2014), pp. 222-230
    Implementation of GMP for the Manufacture of Herbal Preparations: An Efficient and Successful Approach for Initial Process Steps
    B. Wagner, F. Waimer, B. Klier, M. Tegtmeier, B. Steinhoff
  • Zeitschrift für Arznei- und Gewürzpflanzen 19 (2014), p. 66-69
    The implementation of Good Manufacturing Practice (GMP) in the initial process steps of the production of herbal active ingredients
    B. Wagner, F. Waimer, B. Klier, M. Tegtmeier, B. Steinhoff
  • CITplus 17 (2014), No. 12, pp. 6-8
    Plants as a raw material base
    H. Hagels, J. Strube, M. Tegtmeier
  • Zeitschrift für Arznei- und Gewürzpflanzen 19 (2014), pp. 169-177
    Production of plant extracts - from evolution to revolution
    S. Both, M. Tegtmeier, J. Strube
  • Pharmazeutische Zeitung Prisma 19 (2012), pp. 57-60
    Statistical Process Control (SPC) - from "Quality by Testing" to "Real time release" in the univariant approach.
    W. Bühler, M. Farmani, M. Tegtmeier, H. Wätzig
  • Saluplanta Eigenverlag Bernburg, 1st edition (2012)
    Valerian(Valeriana officinalis L.)
    In: Verein für Arznei- und Gewürzpflanzen Saluplanta e.V. Bernburg (ed.) Handbuch des Arznei- und Gewürzpflanzenbaus, Band 4 Arznei- und Gewürzpflanzen A-K, pp. 164-183
    H. Heuberger, U. Lohwasser, R. Schmatz, M. Tegtmeier
  • Saluplanta Eigenverlag Bernburg, 1st edition (2012)
    Benediktenkraut(Cnicus benedictus L.)
    In: Verein für Arznei- und Gewürzpflanzen Saluplanta e.V. Bernburg (ed.) Handbuch des Arznei- und Gewürzpflanzenbaus, vol. 4 Arznei- und Gewürzpflanzen A-K, pp. 256-264
    M. Hammer, W. Junghanns, U. Lohwasser, A. Ryser, M. Tegtmeier
  • Chemie Ingenieur Technik 84 (2012), pp. 880-882
    Plant extraction: key technology for the sustainable use of bio-resources
    M. Tegtmeier
  • Pharmazeutische Industrie 74 (2012), pp. 1078-1084
    Good Agricultural and Collection Practice (GACP) - A Pragmatic and Efficient State-of-the-Art Standard for Cultivation, Collection and Primary Processing of Medicinal Plants
    M. Graf vom Hagen-Plettenberg, B. Klier, M. Tegtmeier, F. Waimer, B. Steinhoff
  • Zeitschrift für Arznei- und Gewürzpflanzen 17 (2012), pp. 105-108
    The importance of Good Agricultural and Collection Practice (GACP) in the production of herbal active ingredients
    M. Graf vom Hagen-Plettenberg, B. Klier, M. Tegtmeier, F. Waimer, B. Steinhoff
  • Zeitschrift für Arznei- und Gewürzpflanzen 17 (2012), pp. 124-128
    Experiments on the cultivation of bearberry(Arctostaphylos uva-ursi (L.) Spreng.)
    M. Sonnenschein, M. Tegtmeier
  • Zeitschrift für Arznei- und Gewürzpflanzen 17 (2012), pp. 189-192
    (Medicinal and spice) plants as a basis for the provision of chemical substances: perspectives and ways
    B. Grohs, M. Tegtmeier
  • LC-GC Europe 24 (2011), pp. 418-422
    Why System Suitability Tests Are Not a Substitute for Analytical Instrument Qualification (Part 3): Performance Qualification (PQ)
    A. Groh, B. Renger, C. Feußner, H. Wätzig, H. Höwer-Fritzen, L. Kaminski, J. Ermer, P. Link, M. Tegtmeier, R.D. McDowall
  • Pharmazeutische Industrie 73 (2011), pp. 1401-1412
    On-going Stability Testing of Herbal Medicinal Products
    C. Höhne, S.O. Kruse, W. Dammertz, U. Kroll, M. Tegtmeier, B. Steinhoff
  • Editio Cantor Verlag Aulendorf, 3rd edition (2011)
    Stability testing in pharmacy
    W. Grimm, G. Harnischfeger, M. Tegtmeier
  • Journal of Pharmaceutical and Biomedical Analysis 51 (2010), pp. 557-564
    Efficient and economic HPLC performance qualification
    L. Kaminski, M. Degenhardt, J. Ermer, C. Feußner, H. Höwer-Fritzen, P. Link, B. Renger, M. Tegtmeier, H. Wätzig
  • Pharmazeutische Industrie 72 (2010), pp. 1166-1174
    Stability Testing of Herbal Medicinal Products
    R. Roth-Ehrang, S. Asche, M. Hubbert, S.O. Kruse, A. Lutz-Röder, F. Poetsch, M. Tegtmeier, M. Wiedemann, B. Steinhoff
  • Wissenschaftliche Verlagsgesellschaft Stuttgart, 5th edition (2009)
    Extrakte und Extraktherstellung
    In: M. Wichtl (ed.) Teedrogen und Phytopharmaka, pp. 26-30
    M. Tegtmeier
  • Deutsche Apotheker Zeitung 149 (2009), No. 10, pp. 54-59
    Health claims for food supplements criticized
    F. Gaedcke, B. Eberwein, O. Kelber, M. Stauss-Grabo, M. Tegtmeier
  • Journal of Pharmaceutical and Biomedical Analysis (2009)
    Efficient and economic HPLC performance qualification
    L. Kaminski, M. Degenhardt, J. Ermer, C. Feußner, H. Höwer-Fritzen, P. Link, B. Renger, M. Tegtmeier, H. Wätzig
  • Saluplanta Eigenverlag Bernburg, 1st edition (2009)
    Toxicology of medicinal and aromatic plants: Fundamentals of the Toxicology of Medicinal and Aromatic Plants
    In: Verein für Arznei- und Gewürzpflanzen Saluplanta e.V. Bernburg (ed.) Handbuch des Arznei- und Gewürzpflanzenbaus, Band 1 Grundlagen des Arznei- und Gewürzpflanzenbaus, pp. 75-80
    M. Tegtmeier, C.P. Siegers
  • Saluplanta Eigenverlag Bernburg, 1st edition (2009)
    Toxicology of medicinal and aromatic plants: Monographs of Medicinal and Spice Plants
    In: Verein für Arznei- und Gewürzpflanzen Saluplanta e.V. Bernburg (ed.) Handbuch des Arznei- und Gewürzpflanzenbaus, Band 1 Grundlagen des Arznei- und Gewürzpflanzenbaus, pp. 80-287
    M. Tegtmeier
  • Govi-Verlag Eschborn, 1st edition (2008)
    Phytopharmaka bei Erkrankungen der Atemwege
    In: S. Heinze (ed.) Naturheilkunde und Homöopathie, pp. 110-129
    M. Tegtmeier
  • Govi-Verlag Eschborn, 1st edition (2008)
    Pflanzliche Immunmodulatoren
    In: S. Heinze (ed.) Naturheilkunde und Homöopathie, pp. 130-132
    M. Tegtmeier
  • Habilitation University of Lübeck (2006)
    The biological hydroxylation of coumarin to umbelliferone
    M. Tegtmeier
  • Deutsche Apotheker Zeitung 146 (2006), No. 30, pp. 74-78
    Thuja occidentalis in phytotherapy
    B. Naser, C. Bodinet, U. Lindequist, M. Tegtmeier
  • Bundesverband der Arzneimittelhersteller Bonn, 3rd edition (2006)
    Qualification and process validation
    E. Anhalt, M. Beringer, A. Böcker, S. Bräuer, S. Fricke, J. Jürgens, W.R. Klein, U. Kontny, N. Kübler, S. Lorenzen, R. Piepho, R. Roth-Ehrang, U. Schiemann, M. Schmidt, H.M. Schwarm, M. Tegtmeier, W. Wächter, C. Wolff, R. Ziegler
  • Phytomedicine 12 (2005), pp. 52-61
    Troxerutin protects the isolated perfused rat liver from a possible lipid peroxidation by coumarin
    B.S. Adam, R. Pentz, C.P. Siegers, O. Strubelt, M. Tegtmeier
  • Evidence-based Complementary and Alternative Medicine 2 (2005), pp. 69-78
    Thuja occidentalis (Arbor vitae): A review of its pharmaceutical, pharmacological and clinical properties
    B. Naser, C. Bodinet, M. Tegtmeier, U. Lindequist
  • Pharmazeutische Zeitung 150 (2005), pp. 18-25
    Phytogalenics: A plea for modern mixed extraction
    M. Tegtmeier, G. Harnischfeger
  • Editio Cantor Verlag Aulendorf, 2nd edition (2004)
    Stabilitätsprüfung in der Pharmazie
    W. Grimm, G. Harnischfeger, M. Tegtmeier
  • International journal of clinical pharmacology and therapeutics 41 (2003), pp. 141-147
    Single copy of variant CYP2A6 alleles does not confer susceptibility to liver dysfunction in patients treated with coumarin
    M. Burian, J. Freudenstein, M. Tegtmeier, B. Naser-Hijazi, H.H. Henneicke-von Zepelin, W. Legrum
  • Pharmazie 55 (2000), No. 2, pp. 93-96
    A new method of capillary electrophoresis for metabolites of coumarin
    M. Tegtmeier, A. Mühlau, D. Dücker, M. Runkel, W. Legrum
  • Experimental Toxicological Pathology 51 (1999), pp. 289-293
    Naringenin and interindividual variability in interaction of coumarin with grapefruit juice
    M. Bourian, M. Runkel, A. Krisp, M. Tegtmeier, J. Freudenstein, W. Legrum
  • Monograph in Hager's Handbook, 5th edition, follow-up volume 2 (1998), pp. 164-170
    Arisaema
    M. Tegtmeier
  • Monograph in Hager's Handbook, 5th edition, subsequent volume 2 (1998), pp. 182-191
    Arum
    M. Tegtmeier
  • Monograph in Hager's Handbook, 5th edition, subsequent volume 2 (1998), pp. 534-536
    Dracunculus
    M. Tegtmeier
  • European Journal of Clinical Pharmacology 53 (1998), pp. 265-269
    The character of inhibition of the metabolism of 1,2-benzopyrone (coumarin) by grapefruit juice in man
    M. Runkel, M. Bourian, M. Tegtmeier, W. Legrum
  • Fruitprocessing 3 (1998), pp. 102-104
    Capillary electrophoresis (CE) an efficient tool for the quality control of fruits as shown for the constitutens of grapefruit
    M. Runkel, A. Mühlau, D. Dücker, M. Tegtmeier, W. Legrum
  • Archiv der Pharmazie - Pharmaceutical and Medicinal Chemistry 331 (1998), pp. 143-148
    7-Aminocoumarins are substrates of cytochrome P450-isozymes
    M. Tegtmeier, W. Legrum
  • Experimental and Toxicologic Pathology 50 (1998), pp. 95-96
    Interindividual variability in the pharmacokinetics of narinigenin and scopoletin determines the differences in interaction of coumarin with grapefruit juice
    M. Bourian, M. Runkel, A. Krisp, M. Tegtmeier, J. Freudenstein, W. Legrum
  • Pharmazie 53 (1998), pp. 486-489
    Asservation of components of essential oils from fresh plants during an excursion
    P. Felske, D. Dücker, M. Tegtmeier, G. Harnischfeger
  • Pharmazeutische Industrie 60 (1998), pp. 801-803
    Use of the single pot technology in the production of drugs from plants
    D. Lindemann, D. Dücker, M. Tegtmeier
  • Planta Medica 63 (1997), p. 289
    Flavones in extracts of Cimicifuga racemosa
  • Beiheft des Institutes für Angewandte Botanik, Hamburg 6 (1197), No. 3, pp. 30-45
    The chemical composition of Baptisia tinctoria L. and its analytical evaluation
    M. Tegtmeier
    D. Struck, M. Tegtmeier, G. Harnischfeger
  • Fresenius Journal of Analytical Chemistry 359 (1997), pp. 516-520
    Detection of scopolin in the grapefruit (Citrus paradisi MACF.)
    M. Runkel, A. Möller, M. Tegtmeier, I. Willigmann, W. Legrum W
  • Analyst 121 (1996), pp. 243-247
    Direct determination of 7-hydroxycoumarin and 7-hydroxycoumarin-glucuronide in urine by using capillary electrophoresis
    D.P. Bogan, R.D. Thornes RD, M. Tegtmeier, E.A. Schafer, R. O'Kennedy
  • Toxicology 108 (1996), pp. 73-78
    Inorganic tin - a new selective inducer of the murine coumarin 7-hydroxylase (CYP2A5)
    B. Emde, M. Tegtmeier, B. Hahnemann, W. Legrum
  • European Journal of Clinical Pharmacology 50 (1996), pp. 226-230
    Metabolic and analytical interactions of grapefruit juice and 1,2-benzopyrone (coumarin) in man
    M. Runkel, M. Tegtmeier, W. Legrum
  • Fruitprocessing 8 (1996), pp. 326-329
    Scopolin and scopoletin as constituents of the grapefruit
    M. Runkel, M. Bourian, I. Willigmann, M. Tegtmeier, W. Legrum
  • Pharmazeutische Zeitung 141 (1996), No. 49, pp. 28-35
    Does the specialist pharmacist for pharmaceutical technology have a future?
    M. Tegtmeier
  • Pharmazie 50 (1995), pp. 73-74
    Liposomes as a tool in experimental pharmacology and toxicology
    M. Tegtmeier, K. Wölfel, C. Sommerlad, W. Legrum
  • European Journal of Pharmaceutics and Biopharmaceutics 40 (1994), No. 5, P. 337-340
    Methods for the reduction of thujone content in pharmaceutical preparations of Artemisia, Salvia and Thuja
    M. Tegtmeier, G. Harnischfeger
  • Pharmazie 49 (1994), pp. 56-58
    The dependence of the thujone content on the extraction method in preparations from Thujae herba
    M. Tegtmeier, G. Harnischfeger
  • Archiv der Pharmazie 327 (1994), pp. 299-302
    Approach to detect substrates suitable to measure the coumarin 7-hydroxylase (Cyp2a-5) - structure-activity relationships
    M. Tegtmeier, W. Legrum
  • Pharmaceutical and Pharmacological Letters 2 (1992), pp. 43-46
    Interactions of coumarin-metabolizing cytochrome P450 isozymes with analogues of umbelliferone
    F. Feil, M. Tegtmeier, B. Hahnemann, W. Legrum
  • Dissertation University of Marburg/Lahn (1992)
    Studies on structure-activity relationships of coumarin 7-hydroxylase using selective inducers
    M. Tegtmeier
  • Biological Reactive Intermediates IV (1990), pp. 353-357
    Selective inducers of the Coh-locus enhance the metabolisms of coumarin- and of quinoline-derivatives but not that of naphthalenes
    K.J. Netter, B. Hahnemann, S.A. Mangoura, F. Feil, M. Tegtmeier, R.T. Mayer, W. Legrum

Career

  • Freelance work in the regulatory environment of medicinal products (GMP/GDP), e.g. as a qualified person, information officer, veterinary vaccine officer and in the support of companies active in the production and processing of (medicinal) plants
  • Appointment as honorary professor at Clausthal University of Technology in the field of bioprocess engineering/phytoextraction
  • Lecturer at the Institute of Thermal Process Engineering and Process Technology at Clausthal University of Technology (including bioprocess engineering and phytoprocess engineering)
  • Habilitation at the Institute for Experimental and Clinical Pharmacology and Toxicology (Director Prof. Dr. Dominiak) with the award of the Venia Legendi for Pharmacology and Toxicology and appointment as a private lecturer at the University of Lübeck
  • 1st prize for pharmaceutical technology for the book "Stability testing in pharmacy"
  • Specialist pharmacist for pharmaceutical technology
  • Qualification as a Qualified Person in accordance with the German Medicines Act (AMG)
  • Specialist pharmacist for pharmaceutical analysis
  • Qualification as manufacturing/control manager in accordance with the German Medicinal Products Act (AMG)
  • Worked in the pharmaceutical industry (Head of Pharmaceutical Technology and Biopharmaceuticals, Head of Production, Member of the Executive Board)
  • Doctorate at the Institute of Pharmacology (Director Prof. Dr. Netter) in Marburg/Lahn
  • Studied pharmacy (license to practice medicine), human medicine (physical examination) and human biology (degree) at the University of Marburg/Lahn